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pentobarbital will lower the level or impact of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Strong or average CYP3A inducers might minimize cobimetinib systemic publicity by >80% and cut down its efficacy.To place this in point of view, a bottle that costs $ 30 in a shop in Mexico,